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Patel – Role of TRPV4 on TLR Responses in J774 Macrophages​ ​

 

Role of TRPV4 on TLR Responses in J774 Macrophages​ ​ (2024)

Undergraduates: Shivam Patel, Palak N. Desai, Assem M. Patel, Willie A. Williams, Swati Sharma, Silvio Antoniak


Faculty Advisor: Silvio Antoniak
Department: UNC Blood Research Center, Pathology and Laboratory Medicine

TRPV4 is a Ca2+ channel which also responds to moderate temperature, changes in cellular osmolarity, mechanical stretch and arachidonic acid (AA) metabolites. TRPV4 is widely expressed within the body. For instance, myeloid cells like neutrophils and macrophages express TRPV4. TRPV4 was indicated to contribute to different non-viral lung injury models. Interestingly, during viral lung infections, the lung experiences changes in osmolarity due to edema formation. Infiltrating myeloid cells experience mechanical forces during transmigration into the lung. The cells are exposed to increased temperatures (fever). And can get in contact with AA metabolites released from platelets. Investigating the role of macrophage expressed TRPV4 in inflammatory responses to virus-like stimulation in vitro.