Interactions of ORG 27569 at CB1 Receptor (2024)

Undergraduates: Abigail Kollu, Nadia Velez, Jacob Beam, Michael Novak

Faculty Advisor: Rachel Penton
Department: Psychology and Neuroscience

---

CB1 receptors are significant to the study of various cannabinoid-based drugs, where they serve to modulate processes such as social behaviors, consumption of food, mood, fear, and anxiety, or even learning abilities and cognition. ORG-27569, a novel drug, has shown to act on the CB1 receptor. Previous researchers identified conformational changes that resulted in an increase in agonist binding and a blockage of G-protein signaling when ORG 27569 is bound to the receptor. The diverse effects of this drug, and the lack of a visualization provides an opportunity for modeling, as a mechanism of advancement for molecular pharmacological understanding. The present model being introduced represents the conformational change of the receptor that results in the blockade of TM6, allowing ORG 27569 to perform as a negative allosteric modulator. By modeling the suspected molecular mechanisms of the drug, pharmacists, biomedical engineers, and/or clinical researchers may be able to gain insight into novel pharmacokinetics of ORG 27569, as a first step to cannabinoid-based drug advancement.