Transition-metal-catalyzed cycloadditions (2013)
Undergraduates: James Lancaster, Andrew Brusoe and Brendan Lainhart
Faculty Advisor: Erik Alexanian
Department: Chemistry
An enantioselective, intermolecular, transition-metal-catalyzed approach to the synthesis of eight-membered carbocycles is described. These [4+2+2] cycloadditions generate multiple carbon-carbon bonds and stereocenters in a single step, improving upon previous carbocycles synthesis strategies. This method demonstrates high regioselectivity, high diastereoselectivity, and good enantioselectivity.