Force Response of Macropinocytosis and Lipid Raft Endocytosis to Enhance Cell Transfection (2013)
Undergraduates: Lauren Scheetz, Kris Ford
Faculty Advisor: Richard Superfine
Department: Biology
This project is exploring the applications on macropinocytosis and lipid raft endocytosis of transfection and magnetofection efficiency and investigates the reasons why macropinocytosis and caveolae-mediated endocytosis are the two most used pathways by particles during transfection. This involves the use of a magnetic force to direct the oligonucleotide-wrapped bead through the cellular membrane. The oscillation of the magnetic force has been found to catalyze the rate as well as changing media before the AC application.