Site-Selective C-H Chlorination via Chloroamide (2015)

Undergraduates: Alex Flores, Ryan K. Quinn

Faculty Advisor: Erik Alexanian
Department: Chemistry

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Currently, there exist very few chlorination reactions that are site-selective due to the indiscriminate reactivity of chlorine radical. Hereby, we demonstrate site-selective C-H chlorination using a chloroamide as the chlorine source, which functions through a radical mechanism but bypasses the formation of indiscriminate free-radical chlorine.